Carbonyl Detoxification Anti Aging Study and Research

It is found that aging is the result of two opposing forces, one which increases the probability of death rate by making the organisms unstable and the other mechanisms such as longevity that prevents repairs or contains damage. The major reason of aging is the toxicants which causes macromolecular damage and physiological disorders. Carbonyl detoxification is the process which cleans the toxic substances created by free stems, glycation and other post translational side reactions and it has been linked to melatonin.

The accumulation of these substances causes aging which leads to lens cataract, cross linked collagen and lipofuscin. Activities like after intense exercise and intense sleep deprivation raises the level of toxic carbonyl. Malondialdehyde (MDA) is one of the intermediate which is responsible for free radical damage as it is a reactive unsaturated carbonyl that can cause cross links important biomacromolecules which can damage structural proteins and nucleic acids. As it is unstable it can easily spread from one place to another and can diffuse from the place of generation to other sites causing more oxidative stress. These carbonyl compounds have very dangerous effect on the reproductive systems.

When the amount of carbonylation increases drastically the human neuron system could not tolerate it any further and would require resting or sleeping. Melatonin a major hormone produced by pineal glands exhibits diurnal rhythm of synthesis. It has been proved by many research and scientists that melatonin is an effective radical cleaner and can cause production of several anti-oxidative enzymes. Thus the toxification cleaning process explains the necessity of sleep in humans or animals during aging.